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KMID : 0351219940260030249
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Korean Journal of Infectious Diseases
1994 Volume.26 No. 3 p.249 ~ p.254
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Oral Herpes Simplex virus Infection in Leukemic patients Undergoing Induction Chemotherapy
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오명돈
김의종/ㅂ가선양/김병국/최강원
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Abstract
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Background:
@EN We tried to assess the rate of oral herpes simplex virus(HSV) infection among the leukemic patients who developed oral ulcers after induction chemotherapy, and to svaluate the role of HSV in the development of ulcerative mucositis
@ES Method:
@EN Leukemic patients who developed oral ulcers after induction chemotherapy were enrolled. To isolate herpes simplex virus from the oral lesions, samples were taken by swabbing the lesions and inoculated in culture of MRC-5 monolayers.
Conventional
tube culture was done, and culture tubes were examined for cytopathicity of monolayers everyday under the Inver ted microscope till 1 week after inoculation. Clinical responses of patients with oral herpes simplex virus infection to acyclovir
treatment
were also evaluated.
@ES Result:
@EN Of the 22 leukemic patients with oral ulcers, cytopathic effects(CPE) typical of herpes simplex virus were observed in 67%(15/22), whereas no CPE developed in the 25 leukemic patients without oral ulcers. Oral ulcers responded to acyclovir
therapy
in 87%(13/15) ot the patients: symptom disappeared after 5 days, and ulcer healed-up after 7 days of acyclovir therapy.
@ES Conclusion:
@EN Oral ulcers in leukemic patients undergoing induction chemotherapy were frequently associated with herpes simplex virus infectios. Herpes simplex virus infection probably play a significant role in the development of oral ulcerative mucositis
in
patients with leukemia
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KEYWORD
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